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Peritendinous / Intrasheath injection

ORTHOFLEX tendon

Treats pain and restores mobility in damaged tendons

An innovative injectable solution combining Hyaluronic Acid and Mannitol for the treatment of tendinopathy. A single injection protocol delivers rapid pain relief and supports the tendon's natural repair process.

ORTHOFLEX tendon product

Product Specifications

Hyaluronic Acid40 mg / 2 ml (obtained by biofermentation)
Mannitol10 mg (free radical scavenger)
Volume2 ml prefilled syringe
Treatment2 injections, once weekly
ApplicationPeritendinous or intrasheath injection
SterilizationAutoclave
TechnologyBiofermentation
Shelf Life2 years
Storage+2°C to +25°C, do not freeze
CertificationsCE, ISO 13485, GMP — Class III Medical Device

What is ORTHOFLEX tendon?

ORTHOFLEX tendon is used for the treatment of pain and reduced mobility due to tendon disorders. Due to its lubricating and visco-elastic properties, a single injection provides rapid pain relief, helping restore the regenerative and restorative functions of the tendon.

ORTHOFLEX tendon consists of 40 mg/2 ml hyaluronic acid obtained by biofermentation, plus 10 mg mannitol — a free radical scavenger that helps stabilize the chains of sodium hyaluronate.

Targeted Indications

Ankle & Foot
  • Achilles tendinopathy
  • Posterior tibial tendinopathy
  • Peroneal tendinopathy
Shoulder
  • Rotator cuff tendinopathy
Elbow
  • Lateral epicondylalgia
  • Medial epicondylalgia
Knee
  • Patellar tendinopathy

How does it work?

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Tendon Gliding & Repair

Due to its lubricating and viscoelastic properties, ORTHOFLEX tendon promotes tendon gliding and the physiologic repair process, reducing pain.

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Anti-Inflammatory Barrier

Its macromolecular meshwork reduces the free passage of inflammatory cells and molecules, acting as a protective barrier around the tendon.

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Nutrient Transport

Acts as a good transport medium for nutrients essential to tendon healing and regeneration.

Administration Protocol

ORTHOFLEX tendon will be injected around the affected tendon or into the tendon sheath, once a week for a total of 2 injections. Several tendons may be treated at the same time. If symptoms return, the treatment can be repeated.

Intrasheath Injection

For tendons with a sheath — ORTHOFLEX tendon is injected into the tendon sheath in the affected area.

Peritendinous Injection

For tendons without a sheath — ORTHOFLEX tendon is injected along the affected tendon (not directly into it).

Ultrasound guidance is recommended during injection to avoid nerve and blood vessel damage.

Tendon Science

How Hyaluronic Acid Heals Damaged Tendons

Tendons contain naturally occurring hyaluronic acid within the tendon sheath and peritendinous tissue. It acts as a lubricant between the tendon and surrounding structures, reducing friction during movement. In tendinopathy, this HA matrix degrades — causing pain, stiffness, and impaired healing.

ORTHOFLEX tendon restores this lost HA (40 mg/2 ml) enhanced with Mannitol — a powerful free radical scavenger that protects the HA chains from enzymatic breakdown, extending the therapeutic effect and supporting the tendon's own regenerative capacity.

  • Restores peritendinous HA for friction-free gliding
  • Mannitol shields HA from free radical degradation
  • Reduces local inflammation without steroids
  • Applicable to multiple tendons in one session
  • Repeatable treatment if symptoms recur
ORTHOFLEX tendon injection detail
See It In Action

ORTHOFLEX tendon — Product Video

Watch how ORTHOFLEX tendon treats tendinopathy and restores mobility in damaged tendons.

Interested in ORTHOFLEX tendon?

Contact our team for product information, pricing, or to request samples.

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